After fifty years of research, and untold millions of research dollars, there are hundreds of published clinical trials of antidepressants. It's when you try to make sense of the results of this great mass of trials that the problems become apparent. The latest attempt to do that is a paper from a German-American collaboration, Rief et. al.'s Meta-analysis of the placebo response in antidepressant trials. The authors set out toRead it all.Determine overall effect sizes of placebo and drug effects in antidepressant trialsIn other words, they wanted to find out how much people improve when given antidepressants, and how much of that improvement is due to the placebo effect.
Friday, 6 March 2009
Someone else on anti-depressants and placebo
Nice post on Neuroskeptic looking at a recent meta-analysis of anti-depressants: